The rapper is a huge fan of Boyle, whose debut album I Dreamed A Dream has topped the album charts in both the U.K. and U.S., and would love to duet with her.
He said: "She's got an amazing voice, and together we'd get everyone dancing. I'm always looking to do something new and she's cool, so I'll ask somebody to let her know."
50 said Susan is on the top of his wish list for collaborations because she's so "hot right now" and he just knows their collaboration would be a big hit.
The unlikely duo would actually make a great team. Susan's high-pitched voice and 50's gangster rap would make quite the collaboration.